From a8691113d7230f8e09ebf5352a67e2c21f24e503 Mon Sep 17 00:00:00 2001 From: Ruibang Luo Date: Thu, 19 Dec 2019 12:26:10 +0800 Subject: [PATCH] Update README.md --- README.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/README.md b/README.md index baad618..2ba6e3d 100644 --- a/README.md +++ b/README.md @@ -6,7 +6,7 @@ Email: rbluo@cs.hku.hk ## Introduction Single-molecule sequencing technologies have emerged in recent years and revolutionized structural variant calling, complex genome assembly, and epigenetic mark detection. However, the lack of a highly accurate small variant caller has limited the new technologies from being more widely used. In this study, we present Clair, the successor to Clairvoyante, a program for fast and accurate germline small variant calling, using single molecule sequencing data. For ONT data, Clair achieves the best precision, recall and speed as compared to several competing programs, including Clairvoyante, Longshot and Medaka. Through studying the missed variants and benchmarking intentionally overfitted models, we found that Clair may be approaching the limit of possible accuracy for germline small variant calling using pileup data and deep neural networks. -This is the formal release of Clair (Clair v2, Dec 2019). You can find the experimental Clair v1 (Jan 2019) at [https://github.com/aquaskyline/Clair](https://github.com/aquaskyline/Clair). The preprint of Clair v2 is available in [bioAxiv](https://biorxiv.org/cgi/content/short/865782v1). +This is the formal release of Clair (Clair v2, Dec 2019). You can find the experimental Clair v1 (Jan 2019) at [https://github.com/aquaskyline/Clair](https://github.com/aquaskyline/Clair). The preprint of Clair v2 is available in [bioRxiv](https://www.biorxiv.org/content/10.1101/865782v2). ---