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Gene imputation #5

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myylee opened this issue Oct 19, 2022 · 0 comments
Open

Gene imputation #5

myylee opened this issue Oct 19, 2022 · 0 comments

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@myylee
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myylee commented Oct 19, 2022

Hi bindSC team,

Thanks for the great package.

I'm following the mouse retina tutorial .

I realized the input to dimensional reduction for X and Z0 only contain a selected number of genes (highly variable in both RNA and gene activity score calculated from scATAC cells) and the subsequent gene expression imputation was also just on these 'gene.use' genes. If I want to impute the all transcriptome, could I modify the imputeZ like this to impute the all genes present in the original rna dataset for the scATAC cell? (see below)

code:
impuZ(X=rna[["RNA"]], bicca = res) # even though the BiCCA was run using reduced dimensions calculated from 'gene.use' genes.

Would greatly appreciate your thoughts on this. Thank you!

Best regards,
Michelle

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