diff --git a/easybuild/easyconfigs/c/CIRCexplorer2/CIRCexplorer2-2.3.8-foss-2021b-Python-2.7.18.eb b/easybuild/easyconfigs/c/CIRCexplorer2/CIRCexplorer2-2.3.8-foss-2021b-Python-2.7.18.eb
index f8b88edbf19..349d6b4d3c9 100644
--- a/easybuild/easyconfigs/c/CIRCexplorer2/CIRCexplorer2-2.3.8-foss-2021b-Python-2.7.18.eb
+++ b/easybuild/easyconfigs/c/CIRCexplorer2/CIRCexplorer2-2.3.8-foss-2021b-Python-2.7.18.eb
@@ -23,7 +23,7 @@ dependencies = [
     ('STAR', '2.7.9a'),
     ('BWA', '0.7.17'),
     ('segemehl', '0.3.4'),
-    ('Pysam', '0.18.0', versionsuffix),
+    ('Pysam', '0.17.0', versionsuffix),
     ('pybedtools', '0.8.2', versionsuffix),
 ]
 
diff --git a/easybuild/easyconfigs/p/Pysam/Pysam-0.18.0-GCC-11.2.0-Python-2.7.18.eb b/easybuild/easyconfigs/p/Pysam/Pysam-0.18.0-GCC-11.2.0-Python-2.7.18.eb
deleted file mode 100644
index 1111d9b3c74..00000000000
--- a/easybuild/easyconfigs/p/Pysam/Pysam-0.18.0-GCC-11.2.0-Python-2.7.18.eb
+++ /dev/null
@@ -1,29 +0,0 @@
-easyblock = 'PythonPackage'
-
-name = 'Pysam'
-version = '0.18.0'
-versionsuffix = '-Python-%(pyver)s'
-
-homepage = 'https://github.com/pysam-developers/pysam'
-description = """Pysam is a python module for reading and manipulating Samfiles.
- It's a lightweight wrapper of the samtools C-API. Pysam also includes an interface for tabix."""
-
-toolchain = {'name': 'GCC', 'version': '11.2.0'}
-
-source_urls = ['https://github.com/pysam-developers/pysam/archive/']
-sources = ['v%(version)s.tar.gz']
-checksums = ['db1ddf41639e4dbb3f94cc9afb14e879bff15690de5b713dec3a81e43f6fa131']
-
-dependencies = [
-    ('Python', '2.7.18'),
-    ('ncurses', '6.2'),
-    ('cURL', '7.78.0'),
-    ('XZ', '5.2.5'),
-]
-
-download_dep_fail = True
-use_pip = True
-
-sanity_pip_check = True
-
-moduleclass = 'bio'
diff --git a/easybuild/easyconfigs/p/pybedtools/pybedtools-0.8.2-GCC-11.2.0-Python-2.7.18.eb b/easybuild/easyconfigs/p/pybedtools/pybedtools-0.8.2-GCC-11.2.0-Python-2.7.18.eb
index e506572279e..62c0c429372 100644
--- a/easybuild/easyconfigs/p/pybedtools/pybedtools-0.8.2-GCC-11.2.0-Python-2.7.18.eb
+++ b/easybuild/easyconfigs/p/pybedtools/pybedtools-0.8.2-GCC-11.2.0-Python-2.7.18.eb
@@ -15,7 +15,7 @@ checksums = ['a184a36099458627e7ef52ea88218f7c00dc9c505b4256ece9ede58b1efa8771']
 dependencies = [
     ('Python', '2.7.18'),
     ('BEDTools', '2.30.0'),
-    ('Pysam', '0.18.0', versionsuffix),
+    ('Pysam', '0.17.0', versionsuffix),
 ]
 
 download_dep_fail = True