diff --git a/itk_wasm_env.bash b/itk_wasm_env.bash
index c3cb7f0a6..77ae9f9b0 100755
--- a/itk_wasm_env.bash
+++ b/itk_wasm_env.bash
@@ -31,5 +31,8 @@ export ITK_WASM_DICOM_TEST_DATA_URLS=${ITK_WASM_DICOM_TEST_DATA_URLS:-$(cat pack
 export ITK_WASM_COMPARE_IMAGES_TEST_DATA_HASH=${ITK_WASM_COMPARE_IMAGES_TEST_DATA_HASH:-$(cat packages/compare-images/package.json | jq -e -r '."itk-wasm"."test-data-hash"')}
 export ITK_WASM_COMPARE_IMAGES_TEST_DATA_URLS=${ITK_WASM_COMPARE_IMAGES_TEST_DATA_URLS:-$(cat packages/compare-images/package.json | jq -e -r '."itk-wasm"."test-data-urls" | join(" ")')}
 
+export ITK_WASM_COMPARE_MESHES_TEST_DATA_HASH=${ITK_WASM_COMPARE_MESHES_TEST_DATA_HASH:-$(cat packages/compare-meshes/package.json | jq -e -r '."itk-wasm"."test-data-hash"')}
+export ITK_WASM_COMPARE_MESHES_TEST_DATA_URLS=${ITK_WASM_COMPARE_MESHES_TEST_DATA_URLS:-$(cat packages/compare-meshes/package.json | jq -e -r '."itk-wasm"."test-data-urls" | join(" ")')}
+
 export ITK_WASM_MESH_IO_TEST_DATA_HASH=${ITK_WASM_MESH_IO_TEST_DATA_HASH:-$(cat packages/mesh-io/package.json | jq -e -r '."itk-wasm"."test-data-hash"')}
 export ITK_WASM_MESH_IO_TEST_DATA_URLS=${ITK_WASM_MESH_IO_TEST_DATA_URLS:-$(cat packages/mesh-io/package.json | jq -e -r '."itk-wasm"."test-data-urls" | join(" ")')}
diff --git a/packages/compare-meshes/package.json b/packages/compare-meshes/package.json
index 050bf62f5..b452f6b70 100644
--- a/packages/compare-meshes/package.json
+++ b/packages/compare-meshes/package.json
@@ -8,6 +8,10 @@
   "itk-wasm": {
     "emscripten-docker-image": "itkwasm/emscripten:latest",
     "wasi-docker-image": "itkwasm/wasi:latest",
+    "test-data-hash": "bafybeiafli6egtmkcgany65po64w67hpqnmgwr5utqo6ycbbz7k5l33llu",
+    "test-data-urls": [
+      "https://github.com/InsightSoftwareConsortium/ITK-Wasm/releases/download/itk-wasm-v1.0.0-b.171/compare-images-test-data.tar.gz"
+    ],
     "package-description": "Compare meshes and polydata for regression testing.",
     "typescript-package-name": "@itk-wasm/compare-meshes",
     "python-package-name": "itkwasm-compare-meshes",
diff --git a/pixi.toml b/pixi.toml
index 72a6ce514..3b208760f 100644
--- a/pixi.toml
+++ b/pixi.toml
@@ -29,6 +29,13 @@ depends-on = ["pnpm-install"]
 outputs = ["packages/compare-images/test/data.tar.gz"]
 description = "Download compare-images test data"
 
+[tasks.compare-meshes-test-data-download]
+cmd = "npx dam download test/data test/data.tar.gz $ITK_WASM_COMPARE_MESHES_TEST_DATA_HASH $ITK_WASM_COMPARE_MESHES_TEST_DATA_URLS"
+cwd = "packages/compare-meshes"
+depends-on = ["pnpm-install"]
+outputs = ["packages/compare-meshes/test/data.tar.gz"]
+description = "Download compare-meshes test data"
+
 [tasks.mesh-io-test-data-download]
 cmd = "npx dam download test/data test/data.tar.gz $ITK_WASM_MESH_IO_TEST_DATA_HASH $ITK_WASM_MESH_IO_TEST_DATA_URLS"
 cwd = "packages/mesh-io"
@@ -188,6 +195,26 @@ cmd = "ctest --test-dir $ITK_WASM_NATIVE_WORKSPACE/compare-images-build"
 depends-on = ["build-native-compare-images"]
 description = "Test compare-images native binaries"
 
+[feature.native.tasks.configure-native-compare-meshes]
+cmd = '''cmake -B$ITK_WASM_NATIVE_WORKSPACE/compare-meshes-build -Spackages/compare-meshes -GNinja
+  -DITK_DIR:PATH=$ITK_WASM_ITK_BUILD_DIR
+  -DBUILD_TESTING:BOOL=ON
+  -DCMAKE_CXX_STANDARD:STRING=20
+  -DCMAKE_BUILD_TYPE:STRING=Debug'''
+depends-on = ["build-itk-wasm", "compare-meshes-test-data-download"]
+outputs = ["native/compare-meshes-build/CMakeFiles/"]
+description = "Configure compare-meshes native binaries"
+
+[feature.native.tasks.build-native-compare-meshes]
+cmd = "cmake --build $ITK_WASM_NATIVE_WORKSPACE/compare-meshes-build"
+depends-on = ["configure-native-compare-meshes"]
+description = "Build compare-meshes native binaries"
+
+[feature.native.tasks.test-native-compare-meshes]
+cmd = "ctest --test-dir $ITK_WASM_NATIVE_WORKSPACE/compare-meshes-build"
+depends-on = ["build-native-compare-meshes"]
+description = "Test compare-meshes native binaries"
+
 [feature.native.tasks.configure-native-mesh-io]
 cmd = '''cmake -B$ITK_WASM_NATIVE_WORKSPACE/mesh-io-build -Spackages/mesh-io -GNinja
   -DITK_DIR:PATH=$ITK_WASM_ITK_BUILD_DIR