diff --git a/code/game/objects/items/circuitboards/machines/machine_circuitboards.dm b/code/game/objects/items/circuitboards/machines/machine_circuitboards.dm
index 2fd3714342c..c7ba71596a6 100644
--- a/code/game/objects/items/circuitboards/machines/machine_circuitboards.dm
+++ b/code/game/objects/items/circuitboards/machines/machine_circuitboards.dm
@@ -462,7 +462,7 @@
 	req_components = list(
 		/datum/stock_part/matter_bin = 1,
 		/datum/stock_part/servo = 1,
-		/obj/item/reagent_containers/cup/beaker = 2)
+		)
 
 /obj/item/circuitboard/machine/circuit_imprinter/offstation
 	name = "Ancient Circuit Imprinter"
@@ -513,7 +513,7 @@
 	req_components = list(
 		/datum/stock_part/matter_bin = 2,
 		/datum/stock_part/servo = 2,
-		/obj/item/reagent_containers/cup/beaker = 2)
+		)
 
 /obj/item/circuitboard/machine/protolathe/offstation
 	name = "Ancient Protolathe"
@@ -601,7 +601,7 @@
 	req_components = list(
 		/datum/stock_part/matter_bin = 2,
 		/datum/stock_part/servo = 2,
-		/obj/item/reagent_containers/cup/beaker = 2)
+		)
 
 /obj/item/circuitboard/machine/techfab/department
 	name = "\improper Departmental Techfab"
diff --git a/code/modules/mining/lavaland/tendril_loot.dm b/code/modules/mining/lavaland/tendril_loot.dm
index 07079516fc1..28c51a38c86 100644
--- a/code/modules/mining/lavaland/tendril_loot.dm
+++ b/code/modules/mining/lavaland/tendril_loot.dm
@@ -60,7 +60,6 @@
 	desc = "A device which causes kinetic accelerators to permanently gain damage against creature types killed with it."
 	id = "bountymod"
 	materials = list(/datum/material/iron = SHEET_MATERIAL_AMOUNT*2, /datum/material/silver = SHEET_MATERIAL_AMOUNT*2, /datum/material/gold = SHEET_MATERIAL_AMOUNT*2, /datum/material/bluespace = SHEET_MATERIAL_AMOUNT*2)
-	reagents_list = list(/datum/reagent/blood = 40)
 	build_path = /obj/item/borg/upgrade/modkit/bounty
 
 //Spooky special loot
diff --git a/code/modules/research/designs.dm b/code/modules/research/designs.dm
index c7c2d1d1d58..a7124bf122b 100644
--- a/code/modules/research/designs.dm
+++ b/code/modules/research/designs.dm
@@ -39,7 +39,7 @@ other types of metals and chemistry for reagents).
 	var/make_reagent
 	/// What categories this design falls under. Used for sorting in production machines.
 	var/list/category = list()
-	/// List of reagents required to create one unit of the product.
+	/// List of reagents required to create one unit of the product. Currently only supported by the limb grower.
 	var/list/reagents_list = list()
 	/// The maximum number of units of whatever is produced by this can be produced in one go.
 	var/maxstack = 1
diff --git a/code/modules/research/designs/misc_designs.dm b/code/modules/research/designs/misc_designs.dm
index 3f4d4b8f8ec..fcbf39ec794 100644
--- a/code/modules/research/designs/misc_designs.dm
+++ b/code/modules/research/designs/misc_designs.dm
@@ -588,7 +588,6 @@
 	id = "paint_remover"
 	build_type = PROTOLATHE | AWAY_LATHE
 	materials = list(/datum/material/iron =HALF_SHEET_MATERIAL_AMOUNT)
-	reagents_list = list(/datum/reagent/acetone = 60)
 	build_path = /obj/item/paint/paint_remover
 	category = list(
 		RND_CATEGORY_TOOLS + RND_SUBCATEGORY_TOOLS_JANITORIAL
diff --git a/code/modules/research/machinery/_production.dm b/code/modules/research/machinery/_production.dm
index e5a426d3a1e..4668753f048 100644
--- a/code/modules/research/machinery/_production.dm
+++ b/code/modules/research/machinery/_production.dm
@@ -45,7 +45,6 @@
 		TRUE, \
 	)
 
-	create_reagents(0, OPENCONTAINER)
 	RefreshParts()
 	update_icon(UPDATE_OVERLAYS)
 
@@ -185,13 +184,6 @@
 /obj/machinery/rnd/production/proc/calculate_efficiency()
 	efficiency_coeff = 1
 
-	if(reagents)
-		reagents.maximum_volume = 0
-
-		for(var/obj/item/reagent_containers/cup/beaker in component_parts)
-			reagents.maximum_volume += beaker.volume
-			beaker.reagents.trans_to(src, beaker.reagents.total_volume)
-
 	if(materials)
 		var/total_storage = 0
 
@@ -207,12 +199,6 @@
 
 	efficiency_coeff = max(total_rating, 0)
 
-/obj/machinery/rnd/production/on_deconstruction()
-	for(var/obj/item/reagent_containers/cup/G in component_parts)
-		reagents.trans_to(G, G.reagents.maximum_volume)
-
-	return ..()
-
 /obj/machinery/rnd/production/proc/do_print(path, amount)
 	for(var/i in 1 to amount)
 		new path(get_turf(src))
@@ -263,14 +249,10 @@
 	print_quantity = clamp(print_quantity, 1, 50)
 	var/coefficient = build_efficiency(design.build_path)
 
-	//check if sufficient materials/reagents are available
+	//check if sufficient materials are available
 	if(!materials.mat_container.has_materials(design.materials, coefficient, print_quantity))
 		say("Not enough materials to complete prototype[print_quantity > 1? "s" : ""].")
 		return FALSE
-	for(var/reagent in design.reagents_list)
-		if(!reagents.has_reagent(reagent, design.reagents_list[reagent] * print_quantity * coefficient))
-			say("Not enough reagents to complete prototype[print_quantity > 1? "s" : ""].")
-			return FALSE
 
 	//use power
 	var/power = active_power_usage
@@ -305,8 +287,6 @@
 
 	//consume materials
 	materials.use_materials(design.materials, coefficient, print_quantity, "built", "[design.name]")
-	for(var/reagent in design.reagents_list)
-		reagents.remove_reagent(reagent, design.reagents_list[reagent] * print_quantity * coefficient)
 	//produce item
 	busy = TRUE
 	if(production_animation)
diff --git a/code/modules/unit_tests/designs.dm b/code/modules/unit_tests/designs.dm
index a9cda144649..0495ebdc7d9 100644
--- a/code/modules/unit_tests/designs.dm
+++ b/code/modules/unit_tests/designs.dm
@@ -18,6 +18,8 @@
 				TEST_FAIL("Design [current_design.type] requires materials but does not have have any build_path or make_reagent set")
 		else if (!isnull(current_design.build_path) || !isnull(current_design.build_path)) // //Design requires no materials but creates stuff
 			TEST_FAIL("Design [current_design.type] requires NO materials but has build_path or make_reagent set")
+		if (length(current_design.reagents_list) && !(current_design.build_type & LIMBGROWER))
+			TEST_FAIL("Design [current_design.type] requires reagents but isn't a limb grower design. Reagent costs are only supported by limb grower designs")
 
 	for(var/path in subtypesof(/datum/design/surgery))
 		var/datum/design/surgery/current_design = new path //Create an instance of each design
diff --git a/modular_skyrat/modules/cellguns/code/medigun_research.dm b/modular_skyrat/modules/cellguns/code/medigun_research.dm
index 86d20adb73a..3971455e44e 100644
--- a/modular_skyrat/modules/cellguns/code/medigun_research.dm
+++ b/modular_skyrat/modules/cellguns/code/medigun_research.dm
@@ -25,28 +25,28 @@
 	name = "Brute II Medicell"
 	desc = "Gives cell-loaded mediguns improved brute damage healing functionality."
 	id = "brute2medicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/gold = SMALL_MATERIAL_AMOUNT * 3, /datum/material/silver = SMALL_MATERIAL_AMOUNT * 3, /datum/material/glass = SMALL_MATERIAL_AMOUNT * 3, /datum/material/uranium = SMALL_MATERIAL_AMOUNT * 3)
 	build_path = /obj/item/weaponcell/medical/brute/tier_2
 
 /datum/design/medicell/burn2
 	name = "Burn II Medicell"
 	desc = "Gives cell-loaded mediguns improved burn damage healing functionality."
 	id = "burn2medicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/gold = SMALL_MATERIAL_AMOUNT * 3, /datum/material/silver = SMALL_MATERIAL_AMOUNT * 3, /datum/material/glass = SMALL_MATERIAL_AMOUNT * 3, /datum/material/uranium = SMALL_MATERIAL_AMOUNT * 3)
 	build_path = /obj/item/weaponcell/medical/burn/tier_2
 
 /datum/design/medicell/toxin2
 	name = "Toxin II Medicell"
 	desc = "Gives cell-loaded mediguns improved toxin damage healing functionality."
 	id = "toxin2medicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/gold = SMALL_MATERIAL_AMOUNT * 3, /datum/material/silver = SMALL_MATERIAL_AMOUNT * 3, /datum/material/glass = SMALL_MATERIAL_AMOUNT * 3, /datum/material/uranium = SMALL_MATERIAL_AMOUNT * 3)
 	build_path = /obj/item/weaponcell/medical/toxin/tier_2
 
 /datum/design/medicell/oxy2
 	name = "Oxygen II Medicell"
 	desc = "Gives cell-loaded mediguns improved oxygen deprivation healing functionality."
 	id = "oxy2medicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/gold = SMALL_MATERIAL_AMOUNT * 3, /datum/material/silver = SMALL_MATERIAL_AMOUNT * 3, /datum/material/glass = SMALL_MATERIAL_AMOUNT * 3, /datum/material/uranium = SMALL_MATERIAL_AMOUNT * 3)
 	build_path = /obj/item/weaponcell/medical/oxygen/tier_2
 
 //Tier 3 Medicells//
@@ -55,28 +55,28 @@
 	name = "Brute III Medicell"
 	desc = "Gives cell-loaded mediguns advanced brute damage healing functionality."
 	id = "brute3medicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/gold = SMALL_MATERIAL_AMOUNT * 3, /datum/material/glass = SMALL_MATERIAL_AMOUNT * 3, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 3, /datum/material/uranium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/titanium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/bluespace = SMALL_MATERIAL_AMOUNT * 3)
 	build_path = /obj/item/weaponcell/medical/brute/tier_3
 
 /datum/design/medicell/burn3
 	name = "Burn III Medicell"
 	desc = "Gives cell-loaded mediguns advanced burn damage healing functionality."
 	id = "burn3medicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/gold = SMALL_MATERIAL_AMOUNT * 3, /datum/material/glass = SMALL_MATERIAL_AMOUNT * 3, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 3, /datum/material/uranium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/titanium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/bluespace = SMALL_MATERIAL_AMOUNT * 3)
 	build_path = /obj/item/weaponcell/medical/burn/tier_3
 
 /datum/design/medicell/toxin3
 	name = "Toxin III Medicell"
 	desc = "Gives cell-loaded mediguns advanced toxin damage healing functionality."
 	id = "toxin3medicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/gold = SMALL_MATERIAL_AMOUNT * 3, /datum/material/glass = SMALL_MATERIAL_AMOUNT * 3, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 3, /datum/material/uranium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/titanium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/bluespace = SMALL_MATERIAL_AMOUNT * 3)
 	build_path = /obj/item/weaponcell/medical/toxin/tier_3
 
 /datum/design/medicell/oxy3
 	name = "Oxygen III Medicell"
 	desc = "Gives cell-loaded mediguns advanced oxygen deprivation healing functionality."
 	id = "oxy3medicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/gold = SMALL_MATERIAL_AMOUNT * 3, /datum/material/glass = SMALL_MATERIAL_AMOUNT * 3, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 3, /datum/material/uranium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/titanium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/bluespace = SMALL_MATERIAL_AMOUNT * 3)
 	build_path = /obj/item/weaponcell/medical/oxygen/tier_3
 
 //Utility Medicells
@@ -89,47 +89,47 @@
 	name = "Clotting Medicell"
 	desc = "Gives cell-loaded mediguns projectile-based coagulation functionality."
 	id = "clotmedicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/gold = SMALL_MATERIAL_AMOUNT * 3, /datum/material/silver = SMALL_MATERIAL_AMOUNT * 3, /datum/material/uranium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5)
 	build_path = /obj/item/weaponcell/medical/utility/clotting
 
 /datum/design/medicell/utility/temp
 	name = "Temperature Adjustment Medicell"
 	desc = "Gives cell loaded-mediguns projectile-based body temperature regulation functionality."
 	id = "tempmedicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/gold = SMALL_MATERIAL_AMOUNT * 3, /datum/material/silver = SMALL_MATERIAL_AMOUNT * 3, /datum/material/uranium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5)
 	build_path = /obj/item/weaponcell/medical/utility/temperature
 
 /datum/design/medicell/utility/gown
 	name = "Hardlight Gown Medicell"
 	desc = "Gives cell-loaded mediguns projectile-based hardlight gown deployment functionality."
 	id = "gownmedicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT)
 	build_path = /obj/item/weaponcell/medical/utility/hardlight_gown
 
 /datum/design/medicell/utility/bed
 	name = "Hardlight Roller Bed Medicell"
 	desc = "Gives cell-loaded mediguns projectile-based hardlight roller bed deployment functionality. Best used on already-horizontal patients."
 	id = "bedmedicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/titanium = SMALL_MATERIAL_AMOUNT * 3, /datum/material/bluespace = SMALL_MATERIAL_AMOUNT * 3)
 	build_path = /obj/item/weaponcell/medical/utility/bed
 
 /datum/design/medicell/utility/salve
 	name = "Empty Salve Medicell"
 	desc = "An incomplete medicell that requires a leaf of aloe to fully realize its potential to provide projectile-embedding-based healing-over-time functionality."
 	id = "salvemedicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT)
 	build_path = /obj/item/device/custom_kit/empty_cell
 
 /datum/design/medicell/utility/body
 	name = "Empty Body Teleporter Medicell"
 	desc = "An incomplete medicell that requires a bluespace slime extract in order to provide projectile-based corpse retrieval functionality."
 	id = "bodymedicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5, /datum/material/bluespace = SHEET_MATERIAL_AMOUNT)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5, /datum/material/bluespace = SHEET_MATERIAL_AMOUNT)
 	build_path = /obj/item/device/custom_kit/empty_cell/body_teleporter
 
 /datum/design/medicell/utility/relocation
 	name = "Oppressive Force Relocation Medicell"
 	desc = "Gives cell-loaded mediguns projectile-based rubbernecker relocation functionality, by dumping them into the Medbay lobby via eigenstate manipulation. Only works in Medbay when fired by authorized users."
 	id = "relocatemedicell"
-	materials = list(/datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5, /datum/material/bluespace = SHEET_MATERIAL_AMOUNT)
+	materials = list(/datum/material/iron = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/plastic = SHEET_MATERIAL_AMOUNT, /datum/material/glass = SHEET_MATERIAL_AMOUNT, /datum/material/plasma = HALF_SHEET_MATERIAL_AMOUNT, /datum/material/diamond = SMALL_MATERIAL_AMOUNT * 5, /datum/material/bluespace = SHEET_MATERIAL_AMOUNT)
 	build_path = /obj/item/device/custom_kit/empty_cell/relocator