From 8cba4184b2d1a28992cbd0127227bcedd5d9d9e8 Mon Sep 17 00:00:00 2001
From: jorge <jorge@jorge-OptiPlex-5090>
Date: Thu, 1 Aug 2024 20:14:12 -0500
Subject: [PATCH] progress for methionine

---
 phaseolus/pvulModelWithBiomass.xml            | 146 ++++++++++++++++--
 ...pvulModelWithBiomass_selectedReactions.txt |  65 +++++++-
 2 files changed, 193 insertions(+), 18 deletions(-)

diff --git a/phaseolus/pvulModelWithBiomass.xml b/phaseolus/pvulModelWithBiomass.xml
index 2d479c9..cdd83f5 100644
--- a/phaseolus/pvulModelWithBiomass.xml
+++ b/phaseolus/pvulModelWithBiomass.xml
@@ -16488,6 +16488,7 @@
                   <rdf:li rdf:resource="http://identifiers.org/biocyc/COMMONBEAN:CPD-14443"/>
                   <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:67139"/>
                   <rdf:li rdf:resource="http://identifiers.org/pubchem.compound/70678847"/>
+                  <rdf:li rdf:resource="http://identifiers.org/kegg.compound/C20258"/>
                 </rdf:Bag>
               </bqbiol:is>
               <bqbiol:hasProperty>
@@ -75373,7 +75374,19 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="PYRROLINECARBREDUCT__45__RXN__45__PRO__47__NAD__47____47__L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE__47__NADH__47__PROTON__46__54__46__" id="PYRROLINECARBREDUCT__45__RXN__45__PRO__47__NAD__47____47__L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE__47__NADH__47__PROTON__46__54__46__" name="PYRROLINECARBREDUCT-RXN-PRO/NAD//L-DELTA1-PYRROLINE_5-CARBOXYLATE/NADH/PROTON.54." reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="PYRROLINECARBREDUCT__45__RXN__45__PRO__47__NAD__47____47__L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE__47__NADH__47__PROTON__46__54__46__" id="R01248" name="PYRROLINECARBREDUCT-RXN-PRO/NAD//L-DELTA1-PYRROLINE_5-CARBOXYLATE/NADH/PROTON.54." reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#R01248">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="http://identifiers.org/ec-code/1.5.1.2"/>
+                  <rdf:li rdf:resource="http://identifiers.org/kegg.reaction/R01248"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="NADH__91__c__93__" stoichiometry="1" constant="true"/>
@@ -77180,6 +77193,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="http://identifiers.org/biocyc/COMMONBEAN:PYRROLINECARBDEHYDROG-RXN"/>
+                  <rdf:li rdf:resource="http://identifiers.org/kegg.reaction/R00707"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -104270,7 +104284,19 @@
           <fbc:geneProductRef fbc:geneProduct="G_PHVUL__46__010G045600"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="RXN__45__14014__45__DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE__47__NADP__47__WATER__47____47__CPD__45__14443__47__NADPH__47__PROTON__46__72__46__" id="RXN__45__14014__45__DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE__47__NADP__47__WATER__47____47__CPD__45__14443__47__NADPH__47__PROTON__46__72__46__" name="RXN-14014-DELTA1-PIPERIDEINE-2-6-DICARBOXYLATE/NADP/WATER//CPD-14443/NADPH/PROTON.72." reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="RXN__45__14014__45__DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE__47__NADP__47__WATER__47____47__CPD__45__14443__47__NADPH__47__PROTON__46__72__46__" id="R04199" name="RXN-14014-DELTA1-PIPERIDEINE-2-6-DICARBOXYLATE/NADP/WATER//CPD-14443/NADPH/PROTON.72." reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#R04199">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="http://identifiers.org/ec-code/1.17.1.8"/>
+                  <rdf:li rdf:resource="http://identifiers.org/kegg.reaction/R04199"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="CPD__45__14443__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="NADPH__91__c__93__" stoichiometry="1" constant="true"/>
@@ -128157,7 +128183,19 @@
           <fbc:geneProductRef fbc:geneProduct="G_PHVUL__46__L001386"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="PYRROLINECARBREDUCT__45__RXN__45__PRO__47__NADP__47____47__L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE__47__NADPH__47__PROTON__46__56__46__" id="PYRROLINECARBREDUCT__45__RXN__45__PRO__47__NADP__47____47__L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE__47__NADPH__47__PROTON__46__56__46__" name="PYRROLINECARBREDUCT-RXN-PRO/NADP//L-DELTA1-PYRROLINE_5-CARBOXYLATE/NADPH/PROTON.56." reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="PYRROLINECARBREDUCT__45__RXN__45__PRO__47__NADP__47____47__L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE__47__NADPH__47__PROTON__46__56__46__" id="R01251" name="PYRROLINECARBREDUCT-RXN-PRO/NADP//L-DELTA1-PYRROLINE_5-CARBOXYLATE/NADPH/PROTON.56." reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#R01251">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="http://identifiers.org/ec-code/1.5.1.2"/>
+                  <rdf:li rdf:resource="http://identifiers.org/kegg.reaction/R01251"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="NADPH__91__c__93__" stoichiometry="1" constant="true"/>
@@ -135383,7 +135421,19 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="RXN__45__14014__45__DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE__47__NAD__47__WATER__47____47__CPD__45__14443__47__NADH__47__PROTON__46__70__46__" id="RXN__45__14014__45__DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE__47__NAD__47__WATER__47____47__CPD__45__14443__47__NADH__47__PROTON__46__70__46__" name="RXN-14014-DELTA1-PIPERIDEINE-2-6-DICARBOXYLATE/NAD/WATER//CPD-14443/NADH/PROTON.70." reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="RXN__45__14014__45__DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE__47__NAD__47__WATER__47____47__CPD__45__14443__47__NADH__47__PROTON__46__70__46__" id="R04198" name="RXN-14014-DELTA1-PIPERIDEINE-2-6-DICARBOXYLATE/NAD/WATER//CPD-14443/NADH/PROTON.70." reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#R04198">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="http://identifiers.org/ec-code/1.17.1.8"/>
+                  <rdf:li rdf:resource="http://identifiers.org/kegg.reaction/R04198"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
         <listOfReactants>
           <speciesReference species="CPD__45__14443__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="NADH__91__c__93__" stoichiometry="1" constant="true"/>
@@ -148686,6 +148736,7 @@
           <speciesReference species="AMMONIA__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="PYRUVATE__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="HOMO__45__CYS__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="PROTON__91__c__93__" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="G_PHVUL__46__001G125400"/>
@@ -148877,6 +148928,65 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
+      <reaction metaid="R01777" id="R01777" name="succinyl-CoA:L-homoserine O-succinyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#R01777">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="http://identifiers.org/ec-code/2.3.1.46"/>
+                  <rdf:li rdf:resource="http://identifiers.org/kegg.reaction/R01777"/>
+                </rdf:Bag>
+              </bqbiol:is>
+              <bqbiol:hasProperty>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000176"/>
+                </rdf:Bag>
+              </bqbiol:hasProperty>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="SUC__45__COA__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="HOMO__45__SER__91__c__93__" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="CO__45__A__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE__91__c__93__" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="R07392" id="R07392" name="S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <annotation xmlns:sbml="http://www.sbml.org/sbml/level3/version1/core">
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#R07392">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="http://identifiers.org/ec-code/4.2.1.109"/>
+                  <rdf:li rdf:resource="http://identifiers.org/kegg.reaction/R07392"/>
+                </rdf:Bag>
+              </bqbiol:is>
+              <bqbiol:hasProperty>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000176"/>
+                </rdf:Bag>
+              </bqbiol:hasProperty>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="CPD__45__1063__91__c__93__" stoichiometry="1" constant="true"/>
+        
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="CPD__45__8999__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="WATER__91__c__93__" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="G_PHVUL__46__005G072900"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
       
       
       
@@ -149958,20 +150068,28 @@
           <speciesReference species="OXYGEN__45__MOLECULE__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="L__45__ALPHA__45__ALANINE__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="L__45__ASPARTATE__91__c__93__" stoichiometry="1" constant="true"/>
-          <speciesReference species="GLN__91__c__93__" stoichiometry="1" constant="true"/>
-          <speciesReference species="VAL__91__c__93__" stoichiometry="1" constant="true"/>
-          <speciesReference species="LEU__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="ARG__91__c__93__" stoichiometry="1" constant="true"/>
-          <speciesReference species="SER__91__c__93__" stoichiometry="1" constant="true"/>
-          <speciesReference species="HIS__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="ASN__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="CYS__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="GLN__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="GLT__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="GLY__91__c__93__" stoichiometry="1" constant="true"/>
-          <speciesReference species="THR__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="HIS__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="ILE__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="LEU__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="LYS__91__c__93__" stoichiometry="1" constant="true"/>
+          
+          <speciesReference species="HOMO__45__CYS__91__c__93__" stoichiometry="1" constant="true"/>
+          
           <speciesReference species="PHE__91__c__93__" stoichiometry="1" constant="true"/>
-          <speciesReference species="TYR__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="PRO__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="SER__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="THR__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="TRP__91__c__93__" stoichiometry="1" constant="true"/>
-          <speciesReference species="CYS__91__c__93__" stoichiometry="1" constant="true"/>
-          <speciesReference species="ASN__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="TYR__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="VAL__91__c__93__" stoichiometry="1" constant="true"/>
+
+
           
           <speciesReference species="ADENINE__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="GUANINE__91__c__93__" stoichiometry="1" constant="true"/>
@@ -150006,6 +150124,7 @@
           <speciesReference species="AICAR__91__c__93__" stoichiometry="1" constant="true"/>
           <speciesReference species="C00672" stoichiometry="1" constant="true"/>
           <speciesReference species="B__45__ALANINE__91__c__93__" stoichiometry="1" constant="true"/>
+          <speciesReference species="PUTRESCINE__91__c__93__" stoichiometry="1" constant="true"/>
           
           
           
@@ -155570,6 +155689,7 @@
       <fbc:geneProduct metaid="G_PHVUL__46__007G250300" sboTerm="SBO:0000243" fbc:id="G_PHVUL__46__007G250300" fbc:name="Phvul.007G250300" fbc:label="G_PHVUL__46__007G250300"/>
       <fbc:geneProduct metaid="G_PHVUL__46__008G210100" sboTerm="SBO:0000243" fbc:id="G_PHVUL__46__008G210100" fbc:name="Phvul.008G210100" fbc:label="G_PHVUL__46__008G210100"/>
       <fbc:geneProduct metaid="G_PHVUL__46__011G0558000" sboTerm="SBO:0000243" fbc:id="G_PHVUL__46__011G0558000" fbc:name="Phvul.011G0558000" fbc:label="G_PHVUL__46__011G0558000"/>
+      <fbc:geneProduct metaid="G_PHVUL__46__005G072900" sboTerm="SBO:0000243" fbc:id="G_PHVUL__46__005G072900" fbc:name="Phvul.005G072900" fbc:label="G_PHVUL__46__005G072900"/>
     </fbc:listOfGeneProducts>
   </model>
 </sbml>
diff --git a/phaseolus/pvulModelWithBiomass_selectedReactions.txt b/phaseolus/pvulModelWithBiomass_selectedReactions.txt
index 8516277..804cbc4 100644
--- a/phaseolus/pvulModelWithBiomass_selectedReactions.txt
+++ b/phaseolus/pvulModelWithBiomass_selectedReactions.txt
@@ -113,6 +113,9 @@ PEPCARBOX__45__RXN
 ALANINE__45__AMINOTRANSFERASE__45__RXN
 ASPAMINOTRANS__45__RXN
 
+##Ala Asp Glt
+ALANINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN
+
 #Krebs basic
 #PYRUVATE-SYNTHASE-MANUAL	No enzymes in P vulgaris
 PEPCARBOXYKIN__45__RXN
@@ -243,9 +246,6 @@ FORMATETHFLIG__45__RXN
 #_3__46__7__46__1__46__9__45__RXN	HYDROXYMUCONATE__45__SALD__91__c__93__
 
 
-
-
-
 #Histidine metabolism
 ATPPHOSPHORIBOSYLTRANS__45__RXN
 HISTPRATPHYD__45__RXN
@@ -287,7 +287,38 @@ ARGINASE__45__RXN
 UREASE__45__RXN
 #NITRIC__45__OXIDE__45__SYNTHASE__45__RXN	Ok but blocked by now. Requires oxygen and produces nitric oxide
 
-#Ser, Gly, Thre
+#Arg, Pro metabolism
+GLUTKIN__45__RXN
+GLUTSEMIALDEHYDROG__45__RXN
+RXN__45__14116
+ORNITHINE__45__GLU__45__AMINOTRANSFERASE__45__RXN
+SPONTPRO__45__RXN
+R01248
+R01251
+
+
+ORNDECARBOX__45__RXN
+PYRROLINECARBDEHYDROG__45__RXN
+#RXN__45__13565
+
+#
+#RXN__45__13564
+
+
+ARGDECARBOX__45__RXN
+AGMATINE__45__DEIMINASE__45__RXN
+N__45__CARBAMOYLPUTRESCINE__45__AMIDASE__45__RXN
+
+#PUTRESCINE__45__OXIDASE__45__RXN
+#PROLINE__45__RACEMASE__45__RXN
+#SPERMIDINESYN__45__RXN
+#AMINOBUTDEHYDROG__45__RXN
+#SPERMINE__45__SYNTHASE__45__RXN
+#RXN0__45__3942
+#RXN__45__9015
+#RXN__45__12089
+
+#Ser, Gly, Thre, lys
 PGLYCDEHYDROG__45__RXN
 PSERTRANSAM__45__RXN
 RXN0__45__5114
@@ -306,6 +337,13 @@ GCVT__45__RXN
 GCVP__45__RXN
 RXN__45__8629
 
+DIHYDRODIPICSYN__45__RXN
+R04198
+R04199
+RXN__45__7737
+DIAMINOPIMEPIM__45__RXN
+DIAMINOPIMDECARB__45__RXN
+
 #Val, ISO, Leu, 
 ACETOLACTSYN__45__RXN
 ACETOLACTREDUCTOISOM__45__RXN
@@ -366,7 +404,24 @@ R07274
 
 
 R00782
-
+R01777
+O__45__SUCCHOMOSERLYASE__45__RXN
+R01286
+#HOMOCYSMET__45__RXN	Requires 5-Methyltetrahydropteroyltri-L-glutamate
+
+
+##Blocked reactions until Met and Spermidine are solved
+S__45__ADENMETSYN__45__RXN
+SAMDECARB__45__RXN
+SPERMIDINESYN__45__RXN
+METHYLTHIOADENOSINE__45__NUCLEOSIDASE__45__RXN
+_5__45__METHYLTHIORIBOSE__45__KINASE__45__RXN
+_5__46__3__46__1__46__23__45__RXN
+R07392
+R82__45__RXN
+R83__45__RXN
+R147__45__RXN
+RXN__45__15650
 
 #R01286
 #DCYSDESULF__45__RXN	Disconnected