diff --git a/ddtrace/contrib/internal/botocore/services/bedrock.py b/ddtrace/contrib/internal/botocore/services/bedrock.py
index fca33630f57..df547e8f095 100644
--- a/ddtrace/contrib/internal/botocore/services/bedrock.py
+++ b/ddtrace/contrib/internal/botocore/services/bedrock.py
@@ -318,7 +318,11 @@ def handle_bedrock_response(
 def patched_bedrock_api_call(original_func, instance, args, kwargs, function_vars):
     params = function_vars.get("params")
     pin = function_vars.get("pin")
-    model_provider, model_name = params.get("modelId").split(".")
+    model_meta = params.get("modelId").split(".")
+    if len(model_meta) == 2:
+        model_provider, model_name = model_meta
+    else:
+        _, model_provider, model_name = model_meta  # cross-region inference
     integration = function_vars.get("integration")
     submit_to_llmobs = integration.llmobs_enabled and "embed" not in model_name
     with core.context_with_data(
diff --git a/releasenotes/notes/botocore-bedrock-cross-region-inference-model-fix-179b7f1ddd6e8e02.yaml b/releasenotes/notes/botocore-bedrock-cross-region-inference-model-fix-179b7f1ddd6e8e02.yaml
new file mode 100644
index 00000000000..be6f6d0dc27
--- /dev/null
+++ b/releasenotes/notes/botocore-bedrock-cross-region-inference-model-fix-179b7f1ddd6e8e02.yaml
@@ -0,0 +1,4 @@
+---
+fixes:
+  - |
+    botocore: fixes bedrock model and model provider interpretation from ``modelId`` when using cross-region inference.
diff --git a/tests/contrib/botocore/bedrock_cassettes/anthropic_message_invoke.yaml b/tests/contrib/botocore/bedrock_cassettes/anthropic_message_invoke.yaml
index a4abf1ac291..dfc0235d6cf 100644
--- a/tests/contrib/botocore/bedrock_cassettes/anthropic_message_invoke.yaml
+++ b/tests/contrib/botocore/bedrock_cassettes/anthropic_message_invoke.yaml
@@ -21,7 +21,7 @@ interactions:
       - !!binary |
         YXR0ZW1wdD0x
     method: POST
-    uri: https://bedrock-runtime.us-east-1.amazonaws.com/model/anthropic.claude-3-sonnet-20240229-v1%3A0/invoke
+    uri: https://bedrock-runtime.us-east-1.amazonaws.com/model/us.anthropic.claude-3-sonnet-20240229-v1%3A0/invoke
   response:
     body:
       string: '{"id":"msg_01E6sPP1ksqicYCaBrkvzna8","type":"message","role":"assistant","content":[{"type":"text","text":"Hobbits
diff --git a/tests/contrib/botocore/test_bedrock.py b/tests/contrib/botocore/test_bedrock.py
index 90c7669cba5..3c91b147a97 100644
--- a/tests/contrib/botocore/test_bedrock.py
+++ b/tests/contrib/botocore/test_bedrock.py
@@ -173,6 +173,7 @@ def test_anthropic_invoke(bedrock_client, request_vcr):
 @pytest.mark.snapshot
 def test_anthropic_message_invoke(bedrock_client, request_vcr):
     body, model = json.dumps(_REQUEST_BODIES["anthropic_message"]), _MODELS["anthropic_message"]
+    model = "us." + model
     with request_vcr.use_cassette("anthropic_message_invoke.yaml"):
         response = bedrock_client.invoke_model(body=body, modelId=model)
         json.loads(response.get("body").read())
diff --git a/tests/contrib/botocore/test_bedrock_llmobs.py b/tests/contrib/botocore/test_bedrock_llmobs.py
index ae2fb7894c6..b7e80651f35 100644
--- a/tests/contrib/botocore/test_bedrock_llmobs.py
+++ b/tests/contrib/botocore/test_bedrock_llmobs.py
@@ -128,6 +128,10 @@ def _test_llmobs_invoke(cls, provider, bedrock_client, mock_llmobs_span_writer,
             }
         with get_request_vcr().use_cassette(cassette_name):
             body, model = json.dumps(body), _MODELS[provider]
+            if provider == "anthropic_message":
+                # we do this to re-use a cassette which tests
+                # cross-region inference
+                model = "us." + model
             response = bedrock_client.invoke_model(body=body, modelId=model)
             json.loads(response.get("body").read())
         span = mock_tracer.pop_traces()[0][0]