figure7_EDPR.py

import numpy as np
import time
import matplotlib.pyplot as plt
from EDPRmodel.EDPRmodel import *
from functions.solve_EDPRmodel import *
from functions.print_final_values import *
from functions.calculate_sigma import *
from functions.calculate_ATP import *

start_time = time.time()

t_dur = 200       # [s]
alpha = 2.0
I_stim = 48e-12   # [A]
stim_start = 10   # [s]
stim_end = 201    # [s]

sol = solve_EDPRmodel(t_dur, alpha, I_stim, stim_start, stim_end)

Na_si, Na_se, Na_di, Na_de, K_si, K_se, K_di, K_de, Cl_si, Cl_se, Cl_di, Cl_de, Ca_si, Ca_se, Ca_di, Ca_de, \
    X_si, X_se, X_di, X_de, n, h, s, c, q, z = sol.y
t = sol.t

my_cell = EDPRmodel(309.14, Na_si, Na_se, Na_di, Na_de, K_si, K_se, K_di, K_de, Cl_si, Cl_se, Cl_di, Cl_de, Ca_si, Ca_se, Ca_di, Ca_de, X_si, X_se, X_di, X_de, alpha, 0.01, 0.01, n, h, s, c, q, z)
#print_final_values(my_cell)

phi_si, phi_se, phi_di, phi_de, phi_sm, phi_dm = my_cell.membrane_potentials()

E_Na_s, E_Na_d, E_K_s, E_K_d, E_Cl_s, E_Cl_d, E_Ca_s, E_Ca_d = my_cell.reversal_potentials()

#print("----------------------------")
#print('elapsed time: ', round(time.time() - start_time, 1), 'seconds')

f1 = plt.figure(1)
plt.plot(t, phi_sm*1000, '-', label='V_s')
plt.plot(t, phi_dm*1000, '-', label='V_d')
plt.title('Membrane potentials')
plt.xlabel('time [s]')
plt.ylabel('[mV]')
plt.legend(loc='upper right')

sigma_i, sigma_e = calculate_sigma(my_cell, t)
ATP_pump, ATP_Ca = calculate_ATP(my_cell, t)

# save to file
np.savez('data/figure7_EDPR', t=t, phi_si=phi_si, phi_se=phi_se, phi_di=phi_di, phi_de=phi_de, phi_sm=phi_sm, phi_dm=phi_dm, \
    E_Na_s=E_Na_s, E_Na_d=E_Na_d, E_K_s=E_K_s, E_K_d=E_K_d, E_Cl_s=E_Cl_s, E_Cl_d=E_Cl_d, E_Ca_s=E_Ca_s, E_Ca_d=E_Ca_d, \
    Na_si=Na_si, Na_se=Na_se, Na_di=Na_di, Na_de=Na_de, K_si=K_si, K_se=K_se, K_di=K_di, K_de=K_de, Cl_si=Cl_si, Cl_se=Cl_se, Cl_di=Cl_di, Cl_de=Cl_de, \
    Ca_si=Ca_si, Ca_se=Ca_se, Ca_di=Ca_di, Ca_de=Ca_de, free_Ca_di=my_cell.free_Ca_di, \
    sigma_i=sigma_i, sigma_e=sigma_e, ATP_pump=ATP_pump, ATP_Ca=ATP_Ca)

#plt.show()